Adipose Tissue Function | Edinburgh Metabolism

Genetic and Molecular Determinants of Adipose Tissue Function

To identify the molecular mechanisms underpinning adipose tissue formation, distribution, and function.

To establish how these mechanisms are (dys)regulated in physiological and pathological contexts such as obesity, diabetes, ageing, and caloric restriction.

To leverage this knowledge for improved strategies to prevent and treat cardiometabolic diseases and other chronic, age-related morbidities.

Intra-organ fat deposition and pancreas lipotoxicity

Structure of the mesothelium associated with adipose tissue.

Immune function of Fat-associated lymphoid clusters.

Bone marrow adipose tissue, diet, ageing, & sex differences in health & disease

Utilising zebrafish and genetic screens to identify molecular mechanisms of adipose formation, distribution and function.

Glucocorticoid-induced adipose dysregulation.

Sexually-dimorphic responses of perivascular adipose tissue to obesity.

Brown adipose tissue formation and function, including human studies and new imaging methods.

Human monogenic lipodystrophy

DNA replication and repair in maintaining adipose health.

Centrosome and mitochondrial function in adipose tissue.